Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study
نویسندگان
چکیده
منابع مشابه
Siah-1 binds and regulates the function of Numb.
The Drosophila Seven in absentia (Sina) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G(1) arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Si...
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Numb Diverts Notch Pathway Off the Tramtrack
with the relationships between the Numb protein and the Notch receptor protein, thus linking cytoplasmic de-Institut fü r Entwicklungsbiologie Universitä t zu Kö ln terminant mechanisms with cell–cell interactions. In a third paper, Zhong et al. (1996) describe observations Federal Republic of Germany on a mouse homolog of Drosophila Numb, which are compatible with the assumption that this prot...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2020
ISSN: 1007-9327
DOI: 10.3748/wjg.v26.i26.3814